THE COMBINATORIAL INDEX

Table of Contents

CHAPTER I. INTRODUCTION

CHAPTER II. COMBINATORIAL SOLID PHASE SYNTHESIS

A. Condensations to prepare amides, esters, ureas, imines, and phosphorous compounds

I.    Amide bond formation

II.   Esterification reactions on solid support

III.  Imine formation on solid support

IV. Urea formation on solid support

V.  Condensations with phosphorous compounds on solid support

B. Carbon-carbon bond formation on solid support

I.   Suzuki reactions on solid support
II.  Organozinc reactions on solid support
III. Stille coupling reactions on solid support
IV. Heck reactions on solid support
V.  Enolate alkylation for carbon-carbon bond formation on solid-support
VI. Solid-phase Wittig reactions
VII. Metathesis reactions on solid support
VIII. Other examples of carbon-carbon bond formation on solid support

C. Mitsunobu reactions on solid support
D. Substitution and addition reactions on solid support
E. Oxidations on solid support
F. Reductions on solid support
G. Preparation of heterocyclic compounds

CHAPTER III. LINKERS FOR COMBINATORIAL SYNTHESIS

AA. Resin derivatization
A. Linkers for carboxylic acids
B. Linkers for amides
C. Linkers for alcohols and amines
D. Linkers for hydrocarbons and other functional groups

CHAPTER IV. ANALYTICAL METHODS FOR SOLID-PHASE SYNTHESIS

A. Standard analytical techniques for solid-phase synthesis
B. Sophisticated analytical techniques for solid-phase synthesis

CHAPTER V. THE PREPARATION OF SOLUTION LIBRARIES AND COMBINED
APPROACHES AT THE SOLUTION/SOLID-PHASE INTERFACE

A. Solution Libraries
B. Resin Capture
C. Support-Bound Reagents

APPENDIX I.   UNNATURAL BIOPOLYMERS
APPENDIX II.  OLIGOSACCHARIDES
APPENDIX III. LIST OF ABBREVIATIONS

INDEX